I am an actress known for my versatility, often taking on roles that require physical transformation. I've won an Oscar for Best Actress for a film where I was almost unrecognizable. I'm also known for my intense dedication to my craft, sometimes going to extreme lengths to embody a character. Before acting, I studied at Harvard and briefly considered a career in medicine. I've been nominated for multiple Academy Awards and am considered one of the most talented actresses of my generation. Who am I?

1. I won an Oscar for playing a real-life serial killer.
2. I studied at Harvard before pursuing acting.
3. I'm known for drastic physical transformations for my roles.
4. I've worked with acclaimed directors like Patty Jenkins and Aaron Sorkin.