I was a large, heavily armed sailing vessel, but was not built for exploration. I was used by multiple nations, often in a contested region. My most famous commander was also a figure known for other reasons, and I was eventually destroyed in battle. What am I?

1. I was a ship of the line, carrying many guns.
2. I saw action in the Mediterranean Sea.
3. My commander was involved in the Battle of Trafalgar.
4. My final battle involved a combined fleet.